King Felipe VI and Queen Letizia said they were following news of the disaster with “with great concern”.
“We extend our most heartfelt condolences to the relatives and loved ones of the dead, as well as our love and wishes for a swift recovery to the injured,” the royal palace said on X.
“My thoughts are with the victims, their families and the entire Spanish people. France stands by your side,” Macron wrote on social media.
In 2013, Spain suffered its worst high-speed train derailment in Galicia, north-west Spain, which left 80 people dead and 140 others injured.
